December 7, 2022

on a Weight Loss Drug That… Works?

The Consistency Project

on a Weight Loss Drug That... Works?

00:00 / 24:57

The soundbyte summary: Semaglutide (sold as Wegovy) acts on appetite centers in the brain and in the gut, producing feelings of satiety and reducing cravings. In a clinical trial, one-third of participants experienced 20% weight loss, which is unprecedented for a weight loss drug.

The Consistency Project

on a Weight Loss Drug That... Works?

00:00 / 24:57

Topics include:

How our metabolism regulates energy balance;
How the body fat defends against fat loss;
How the drug semaglutide (sold as Wegovy or Ozempic) works and how effective it has been;
Drawbacks to taking the drug;
Who should consider taking it versus making basic diet & lifestyle changes?

Referenced Articles

Guyenet & Schwartz, 2012. Rats are attracted to high-fat diet.
Hall & Kahan, 2018. Maintenance of lost weight and long-term management of obesity.
Wilding et al., 2021. Semaglutide clinical trial where >70% of participants experienced 10% weight loss.
Rubino et al., 2021. Semaglutide clinical trial where participants regained weight after they went off the drug.

Referenced Podcasts

On Five Takeaways from a Book Worth Reading (Burn)

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