The soundbite summary: Exercise causes micro-damages that train the body’s defense & repair mechanisms – both are needed to prevent chronic disease.
• Healthspan versus lifespan and how industrialization changes their trajectories
• What is the “Active-grandparent hypothesis” (why do we live well beyond our reproductive years)?
• Exercise as a stress that causes damage necessitating stronger defense and repair mechanisms
• Why preventing diseases like heart disease and cancer requires strong defense and repair mechanisms
• How to optimize health via exercise (is foraging the new exercise? Is more better?)
• Why could exercise be more important than nutrition for disease prevention
• How our view of what the golden years “should be” may be at odds with optimal health
Lieberman, et al. 2021. The active grandparent hypothesis.
Paffenbarger et al., 1986. Physical activity and all-cause mortality with Harvard alumni.
Piercy et al., 2018. 80% of Americans are insufficiently active.
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